New Anvisa Regulation in Brazil: Over 500 Cosmetic Registrations Canceled; TPO and DMPT Substances Fully Banned!
The Brazilian National Health Surveillance Agency (Anvisa) has officially announced the cancellation of all cosmetic product registrations containing TPO (Diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide) and DMPT (N,N-dimethyl-p-toluidine). More than 500 products are affected, primarily within the professional nail care sector, such as UV gel polishes and phototherapy gels. As a result, the production, sale, and use of these products are now strictly prohibited throughout Brazil. 01 | Regulatory Background: From Prohibition to Total Removal in 90 Days In October 2025, Anvisa issued Resolution RDC 995/2025, which added TPO and DMPT to the list of prohibited substances and established a 90-day transition period. Following the expiration of this period: 02 | Why the Ban? Internationally Verified Health Risks These two components were widely used as photoinitiators or stabilizers in gel nail polishes and LED/UV-cured nail systems. However, international scientific studies have confirmed severe health risks: Anvisa emphasized that these measures are essential to […]